In 1886, an economic boom sparked by the discovery of natural gas in Muncie, Indiana, attracted an array of residents to the area. Hoping to raise interest in art, a group of women formed the Art Students' League in 1892. After the success of multiple art exhibits, the group formed the Muncie Art Association in 1905. The group's objectives included organizing annual free exhibitions and purchasing one work of art each year to begin a permanent collection.

The works in the permanent collection were displayed in local high school corridors until 1918, when the Ball brothers founded the Indiana State Normal School. The collection found a new home at the school, which later became Ball State Teachers College and is now Ball State University. Eventually the collection was moved to the school's North Quadrangle Library.

In 1931, plans began for a new art building to house the expanding collection. The Fine Arts Building opened in 1935 and remains the home of the collection. In January 1991, the gallery's official name became the Ball State University Museum of Art.  

Construction to expand the museum began in 2000. The $8.5 million project added 5,230 square feet to the facility, doubling the number of works of art displayed. The newly renovated museum opened in September 2002.

The museum was renamed to the David Owsley Museum of Art on October 6, 2011 in honoring his generous donations. With the donations, the museum plans to undergo yet another renovation by adding art galleries in vacated rooms within the Fine Arts Building. Construction will begin during the summer of 2012 and complete in 2013.