Domenico Tojetti (1807–1892) was an Italian American painter.

Born in Rocca di Papa, near Rome, the artist frequented the Roman circle of the Torlonia Princes, providing frescos in the ballroom of Villa Torlonia under the direction of his teacher, Francesco Coghetti.

The artist provided also frescoes in the churches of Rome, including the Basilica di San Paolo fuori le Mura and Sant'Agnese fuori le Mura. In this period he developed friendships with Constantino Brumidi, who moved to the United States in 1852, and with Leonardo Massabò.

In 1867 Tojetti moved with his family to Guatemala, then Mexico, and finally to San Francisco, California, where he produced paintings for churches, public and private buildings.

He died in San Francisco in 1892.